In this podcast episode, McCall McPherson, a medical professional from the Modern Thyroid Clinic, explores the benefits of GLP-1 agonists, originally developed for diabetes treatment, in aiding weight loss and improving overall health. She highlights the medications' ability to reduce inflammation, enhance metabolic function, and offer potential neuroprotective benefits. McCall shares her experiences with patients, particularly women with thyroid dysfunction, who struggle with weight loss despite their efforts. She advocates for the use of GLP-1 medications as part of a comprehensive approach to health, emphasising the importance of integrating these treatments with healthy lifestyle choices.
In this episode, we delve into the revolutionary class of medications known as GLP-1 agonists. For those unfamiliar, GLP-1 agonists are primarily recognized for their role in weight loss and diabetes management. However, the benefits of these medications extend far beyond just shedding pounds. As the founder of the Modern Thyroid Clinic, I have witnessed firsthand how these medications can transform lives, particularly for individuals struggling with weight loss due to underlying health conditions.
GLP-1, or glucagon-like peptide-1, is a naturally occurring compound in our bodies that plays a crucial role in regulating blood sugar levels and appetite. Initially developed as diabetes medications, GLP-1 agonists like semaglutide (found in drugs such as Ozempic and Wegovy) were observed to induce significant weight loss in patients. Over the years, these medications have gained FDA approval for weight management, highlighting their dual purpose in treating both diabetes and obesity.
It's essential to understand that GLP-1 agonists are not new; they have been used for decades in diabetes treatment, providing us with extensive long-term data on their safety and efficacy. As we age, our body's natural GLP-1 production can diminish, leading to increased hunger and cravings, as well as inflammation. This decline can make it challenging for some individuals to lose weight through traditional methods like diet and exercise alone.
There is a prevalent misconception that individuals who struggle with weight loss are simply lazy or unwilling to put in the effort. However, many of my patients, particularly women with thyroid dysfunction, are dedicated to their health. They follow strict diets and exercise regimens but still find it nearly impossible to lose weight. This reality is often overlooked in society, and it has been a personal mission of mine to advocate for those who face these challenges.
In my practice, I have seen countless women who, despite their best efforts, cannot achieve their weight loss goals. This struggle can lead to feelings of frustration and inadequacy, especially when they are doing everything "right." The introduction of GLP-1 agonists into our treatment protocols has been a game-changer, allowing these individuals to regain control over their weight and, consequently, their lives.
While weight loss is a significant benefit of GLP-1 medications, it is merely a byproduct of their broader health impacts. Here are some of the key benefits that I have observed in my patients:
GLP-1 agonists not only facilitate weight loss but also help heal metabolic dysfunction. Many patients experience improvements in insulin sensitivity, reversal of prediabetes, and overall metabolic flexibility. This healing allows individuals to maintain their weight loss and lose weight with effort even after discontinuing the medication.
Chronic inflammation is a core driver of many diseases, including autoimmune conditions like thyroid disorders. In my experience, GLP-1 agonists have shown remarkable anti-inflammatory effects. Patients often report significant reductions in inflammatory markers within days of starting treatment, leading to improved overall health and well-being.
Contrary to the belief that GLP-1 medications can harm gut health, many patients experience better digestion and reduced bloating. The anti-inflammatory properties of these medications can help heal the gut lining, leading to improved tolerance of various foods.
Emerging research suggests that GLP-1 agonists may have protective effects against neurodegenerative diseases like Alzheimer's and Parkinson's. Studies indicate that these medications can reduce brain atrophy and potentially slow the progression of cognitive decline.
Despite the numerous benefits, there are concerns regarding the safety and side effects of GLP-1 agonists. Common side effects include nausea and gastrointestinal discomfort, which are often dose-dependent. In my practice, we have adopted a microdosing approach, tailoring doses to individual needs. This strategy has significantly reduced side effects, allowing patients to experience the benefits of GLP-1 medications without the discomfort.
One of the most significant misconceptions is the fear of thyroid cancer associated with GLP-1 agonists. Early studies in rats indicated a potential risk, but these findings have not been replicated in human studies. The FDA's warnings stem from these animal studies, and it is crucial to understand that the risk of thyroid cancer in humans taking GLP-1 medications is not statistically significant. The only contraindication for these medications is a personal or family history of medullary thyroid carcinoma, which is a rare form of thyroid cancer.
Weight loss, whether achieved through lifestyle changes or medications like GLP-1 agonists, can lead to an increased risk of pancreatitis. This risk is not exclusive to GLP-1 medications; it can occur with any significant weight loss. However, it is crucial to note that GLP-1 medications do not inherently increase the risk of pancreatic cancer. Instead, they may elevate the risk of pancreatitis, which can be managed by ensuring gradual weight loss and appropriate dosing of the medication.
Another common concern is the potential for muscle mass loss, often referred to as "Ozempic face." This notion is misleading. The loss of muscle mass is primarily a result of severe calorie deficits and inadequate protein intake, not the medication itself. By managing the dosage of GLP-1 medications and ensuring adequate protein consumption, patients can maintain or even increase their muscle mass while using these drugs.
It is vital to understand that GLP-1 medications should not be viewed as a standalone solution. They are most effective when used in conjunction with a healthy lifestyle. Patients must focus on nutrition, exercise, and overall wellness to achieve long-term success. Those who enter a GLP-1 treatment plan without a solid foundation of healthy habits may find it challenging to maintain their results once they discontinue the medication.
I want to emphasise that using GLP-1 medications does not equate to laziness or taking the easy way out. Many individuals who turn to these medications have exhausted all other options and require additional support to achieve their health goals. It is essential to recognize the diverse needs of patients and provide them with effective solutions.
When considering GLP-1 medications, it is crucial to work with a clinician who tailors the treatment to individual needs. Questions to ask your provider include:
These questions ensure that patients receive personalised care and support throughout their treatment journey.
Microdosing GLP-1 medications is an emerging practice that allows patients to use the least amount of medication necessary to achieve the desired effects. This approach can vary significantly from person to person, and it is essential to work closely with a clinician to determine the appropriate dosage.
Research indicates that GLP-1 medications can be used safely for extended periods, making them a viable option for long-term management of weight and metabolic health. However, it is essential to monitor progress and make adjustments as needed.
After discontinuing GLP-1 medications, many patients experience metabolic improvements. However, it is important to note that inflammation may return, as GLP-1 medications influence several inflammatory pathways. This highlights the importance of maintaining a healthy lifestyle even after stopping the medication to sustain the benefits achieved during treatment.
There is a growing interest in natural GLP-1 boosters, some of which may offer benefits. However, it is crucial to set realistic expectations, as these natural alternatives will not provide the same effects as prescription GLP-1 medications.
In summary, GLP-1 agonists represent a significant advancement in the management of weight and metabolic health. They offer numerous benefits, including weight loss, inflammation reduction, and improved overall health. However, it is essential to approach their use thoughtfully, integrating them into a comprehensive lifestyle plan and working closely with a knowledgeable clinician.
As we continue to explore the potential of GLP-1 medications, I encourage you to stay informed and consider how they may fit into your health journey. Thank you for tuning in, and I look forward to addressing more questions and topics in future episodes.
